Non-eosinophilic asthma: importance and possible mechanisms
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چکیده
منابع مشابه
Non-eosinophilic asthma: importance and possible mechanisms.
There is increasing evidence that inflammatory mechanisms other than eosinophilic inflammation may be involved in producing the final common pathway of enhanced bronchial reactivity and reversible airflow obstruction that characterises asthma. A review of the literature has shown that, at most, only 50% of asthma cases are attributable to eosinophilic airway inflammation. It is hypothesised tha...
متن کاملOCCASIONAL REVIEW Non-eosinophilic asthma: importance and possible mechanisms
There is increasing evidence that inflammatory mechanisms other than eosinophilic inflammation may be involved in producing the final common pathway of enhanced bronchial reactivity and reversible airflow obstruction that characterises asthma. A review of the literature has shown that, at most, only 50% of asthma cases are attributable to eosinophilic airway inflammation. It is hypothesised tha...
متن کاملCellular Mechanisms Underlying Eosinophilic and Neutrophilic Airway Inflammation in Asthma
Asthma is a phenotypically heterogeneous chronic disease of the airways, characterized by either predominant eosinophilic or neutrophilic, or even mixed eosinophilic/neutrophilic inflammatory patterns. Eosinophilic inflammation can be associated with the whole spectrum of asthma severity, ranging from mild-to-moderate to severe uncontrolled disease, whereas neutrophilic inflammation occurs most...
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T he concept that there may be heterogeneity of the underlying pathology of asthma has a long pedigree: 80 years ago, Rackemann suggested that a subgroup of patients with intrinsic asthma had disease driven by bacterial infection of the upper and lower respiratory tract and the authors of an early postmortem study were struck by the heterogeneity of lower airway inflammatory response in fatal a...
متن کاملAssessment and reproducibility of non-eosinophilic asthma using induced sputum.
BACKGROUND The assessment of eosinophilic airway inflammation using induced sputum identifies a corticosteroid-responsive subtype that can be used to guide anti-inflammatory therapy. The stability of airway inflammation in asthma over time is not known, yet this information is crucial to inflammation-based patient management. OBJECTIVE The aim of this study was to determine the reproducibilit...
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ژورنال
عنوان ژورنال: Thorax
سال: 2002
ISSN: 0040-6376
DOI: 10.1136/thorax.57.7.643